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(2023) 9:e14199

A mutation in ubiquitin C-terminal hydrolase L1 (UCH-L1), which is associated with familial PD, was reported to inhibit CMA autophagy by interacting with the lysosomal receptor of CMA LAMP-2A [67]

Peripheral inflammatory cytokines can enter the CNS through the blood-brain barrier (BBB) or specific transporters [64]

Samples were mounted onto glass slides using water as a medium and investigated under a Leica (DMI 6000 CS AFC Bino inverted microscope) TCS SP8 instrument

By day 6, mitochondrial function recovered, with significantly increased expression of both mitochondrial transcription factor A and mitofusin-2 , and these improvements persisted at day 10