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Chronic inflammation is a major contributor to joint pain and discomfort (Sikora et al., 2021)
doi: 10.1016/0006-291x(89)91141-8
doi: 10.1016/j.cj.2024.02.011 43 DuoduK
doi: 10.1016/j.freeradbiomed.2010.12.028
Notably, elevated levels of 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE], a subclass of eicosanoids, activate the intracellular cation channel transient receptor potential vanilloid one and mediate endothelial dysfunction in DM (Otto et al., 2020)
