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Copper Overload Due to Zinc Deficiency Copper and zinc have a complex interplay in the body

Evidence Based Care

By gaining a deeper understanding of iron overload and its complex mechanisms in the heart, accurately assessing new therapeutic approaches based on chelators will help further improve patient outcomes

While millimolar concentrations may not accurately reflect in vivo conditions, the pathophysiological importance of these findings is underscored by the localization of both -synuclein and metal ions at synapses

Attribution of the 385 s peak to SOD1 was also supported by the presence of a prominent zinc peak at this timepoint, reflecting the native copper/zinc binding of the SOD1 holoenzyme (Fig