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[3] So if youve always thought your cycle was longer than the norm, youre probably not alone

Such rhythms still persist in constant darkness (free-running conditions), and can be reset by exposure to external signals including light (entrainment)

The two major markers of the disease, amyloid (A) and tau protein are both closely associated with oxidative stress (Tamagno et al., 2021)

NEWS IN BRIEF 2025s FDA approvals by regulatory designations Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature Reviews Drug Discovery 25 , 163 (2026) doi:

Cell 153 , 480492 (2013)