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Most work based on crystal structures and molecular simulations indicates that Na + accesses this site from the extracellular space (Strasser et al., 2015), but for there are also simulations predicting that it can bind from the intracellular side (Selvam et al., 2018)

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42 These findings follow on many years of work to develop electrophilic molecules, notably aromatic thioesters, that target the Cys residues in one of the two retroviral nucleocapsid protein ZF domains of the Gag polyprotein (Figure 3C), mediating zinc release or zinc ejection, as a promising antiretroviral strategy

The nutrient lingers in the bloodstream, building up in a way that may not be ideal