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10.1186/s12891-024-07411-3 187 YueweiS.IsabelA.DeC.MjM.AfM.MT.et al (2014)

The upregulation and activation of 7nAChR subsequently activate several signaling pathways, including neuroprotective PI3K/Akt and Nrf2 pathways, then suppression of pro-apoptotic caspase-3, and suppression of NF-B that reduce the expression of proinflammatory cytokines such as IL-1, and TNF- [50, 86]

J Hypertens 19(8):13691377 Simko F, Pechanova O, Repova Bednarova K, Krajcirovicova K, Celec P, Kamodyova N, Zorad S, Kucharska J, Gvozdjakova A, Adamcova M, Paulis L (2014) Hypertension and cardiovascular remodelling in rats exposed to continuous light: Protection by ACE-inhibition and melatonin

The overall regulatory state of pyroptosis is shown in Fig