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Cytokine release was measured in serum supernatants and compared to negative controls (blood incubated for 4 h in the absence of IMC-M113V) using an MSD immunoassay (V-PLEX proinflammatory kit

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Diagnosis As Wilsons disease is an inherited genetic condition (caused by a mutated or faulty gene called ATP7B), genetic testing might be the most robust diagnostic technique, since the liver and neurological symptoms displayed may not be specific enough to differentiate Wilsons disease from other liver diseases, or from a psychological illness

Nef S, Verma-Kurvari S, Merenmies J, Vassalli JD, Efstratiadis A, Accili D, Parada LF: Testis determination requires insulin receptor family function in mice

Disruption of lipid rafts results in loss of capacitive Ca 2+ entry and dysregulation of Ca 2+ -regulated AC isoforms (Dessauer et al., 2017)