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Caruso I, Sarzi Puttini P, Cazzola M, Azzolini V

L-carnitine activates the AKT/FOXO3a/MaFbx pathway, increases p70S6k protein expression, and promotes p-p70S6k phosphorylation to ameliorate the muscle wasting of cancer cachexia in CT26-bearing mice In our in vivo study, p-Akt and p-FOXO3a were decreased in CT26 tumor-bearing mice, and FOXO3a and MAFbx were increased, which could partly explain the muscle loss in the cachectic mice (Fig

doi: 10.1016/j.jacbts.2018.05.004 [DOI] [PMC free article] [PubMed] [Google Scholar] 108

That is an early step toward neurodegeneration This is the gut-brain connection people throw around but rarely explain properly