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Prompted by report that RXR is important in liver regeneration (Imai et al., 2001), we examined changes in GSH homeostasis in mice with liver specific RXR deletion (Wu et el., 2004)

doi: 10.1242/jcs.259455

In summary, after long-term administration of GLPs, by maintaining glucose and lipid metabolism homeostasis, exerting antioxidative, inflammation-reducing, anti-fibrotic impacts, and regulating gastrointestinal-heart axis, the physiological state and pathological findings in rats remained normal, with no obvious organ damage observed, indicating good safety

C-type lectin receptors (CLRs) CLRs serving as phagocytic PRRs, exhibit a differentiating mechanism compared to signaling-activated PRRs

however, they can also be induced by various types of stress