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While it is considerably cheaper, L-carnitine does not have the same bioavailability as acetyl L-carnitine (ALC) and has not been used in studies on mitochondrial decline

It can pass easily to the brain and is both water and fat-soluble Liu and colleagues tested aged rats with oral acetyl-L-carnitine and lipoic acid to see if the supplementation reduced mitochondrial aging in the brain [1] A group from Oregon State University reviewed the literature and suggested that together, acetyl-L-carnitine and lipoic acid were able to protect the heart from aging as well as reverse age-related changes [2]

Carnitine Biosynthesis Carnitine in humans is derived from diet and de novo biosynthesis using lysine and methionine

P.DjouadiF.Prip-BuusC.GobinS.MunnichA.BastinJ

Cytochrome c