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Furthermore, when mGluR2 is antagonized, the demyelination of injured nerves is inhibited in vivo [272]

European Heart Journal , 42 (48), 49054914

These measures are invaluable for screening, monitoring, and proof-of-concept, but a change in an imaging fat fraction or a blood panel is a surrogate: it supports, but does not by itself establish, the biopsy endpoints regulators require

it is the difference between maintenance dosing and therapeutic dosing