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May support slow-wave and REM sleep architecture, per a placebo-controlled polysomnography study in younger and older adults (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)

But in neurodegenerative diseases, they can become abnormally twisted and form tangles that disrupt neuronal function and lead to cognitive decline

[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Lacher SE, Levings DC, Freeman S, Slattery M
Collectively, these findings indicate that JAB1 enhances breast cancer cell growth, invasiveness, and stem cell-like properties through the stabilization of CUL4B protein

This helps to regulate sleep, mood and appetite cycles, as well as, help with cholesterol, metabolism and brain health
