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Description
GLP-1 receptor agonists like semaglutide and tirzepatide act on incretin pathways through GLP-1 and GIP receptors, with central appetite suppression and slowed gastric emptying as primary mechanisms
The STEP 5 trial demonstrated that continued treatment for 104 weeks maintained weight loss, while the STEP 1 extension study showed that discontinuing semaglutide at 68 weeks led to two-thirds of the weight lost being regained within a year
Clinical Endocrinology, 49(5), 659664
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This vitamin is essential to converting fat into energy
