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Alzheimers disease: diverse aspects of mitochondrial malfunctioning
Ferroptosis can be experimentally induced by direct inhibition of Gpx4 via Ras-selective lethal small molecule 3 (RSL3) or by genetic knockdown or deletion of Gpx4 (Yang et al., 2014)
Smoking and excessive alcohol intake are well-known contributors to oxidative stress, depleting antioxidant reserves and increasing ROS production
