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Description
Apelin Mechanisms of action Apelin expression diminishes in skeletal muscle with aging across both rodents and humans
Plant Mol Biol 28:113122

Table 1 Regulation of SIRT1 expression

A previous study had also shown that SIRT1 activation promotes antioxidant molecule production and decreases pro-apoptotic proteins through FOXO1 activation, thus protecting against MI/R lesions (Hsu et al., 2010)

Clinical trials found no associated increase in arrhythmias or adverse cardiovascular events
