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doi: 10.1152/ajpgi.1990.259.4.G530

Similarly, alcohol and over-the-counter pain relievers like acetaminophen are heavily metabolized by the liver and rapidly deplete the body's natural glutathione stores

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Total antioxidant and glutathione levels have been shown to be lower within the plasma of non-medicated, medicated, first-episode and chronic schizophrenia patients ( Results from in vivo MRS studies of glutamate/glutamine concentrations in schizophrenia, whilst inconsistent, have highlighted that sub-grouping patients on residual schizophrenia (long-term negative symptoms/impairments) revealed reduced, highly correlated, GSH, glutamate and glutamine concentrations in the ACC ( It has been suggested that, in schizophrenia, redox dysregulation and subsequent oxidative stress may be limited to a specific subgroup representing ~1 third of patients ( Genetic Studies Genome wide association studies have shown an association between gene polymorphisms for oxidative stress and schizophrenia ( Animal Models Higher levels of reactive species within mitochondria have been found in the brains of ketamine-induced rat models of schizophrenia compared to wild-type controls ( Evidence of redox dysregulation is seen in other common neurodevelopmental animal models of schizophrenia

doi: 10.1186/s13075-014-0432-1 74 MatasJGarcaCPobleteDVernalROrtloffALuque-CamposNet al
