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A smaller placebo-controlled trial showed that oral administration of 300 mg/day of coenzyme Q 10 for 48 to 96 months moderately improved motor symptoms in treated patients (with Levodopa) with re-emerging symptoms but not in patients at an early stage of the disease (67)

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Fecal microbiota transplantation Fecal microbiota transplantation, also referred to as stool transplantation or bacteriotherapy, involves transferring fecal matter from a healthy donor into the gastrointestinal tract of a patient [149]

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Healthcare providers should consider this limited evidence base when making treatment decisions and should discuss these limitations with patients

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