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Toosendanin induced hepatotoxicity via triggering PERK-eIF2alpha-ATF4 mediated ferroptosis

There are more nerves in the muscle in the thigh than in the deltoid muscle, and it is easier to find the safe place to do the injection in the upper arm (which is why this is a common used place to give vaccinations i.m.)

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Unsurprisingly, most clinical trials with NAC have resulted in lack of therapeutic efficacy [12-16]
