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Once in the nucleus, it binds to specific transcription factors and DNA elements particularly antioxidant response elements (ARE) that are regulated by the stress-responsive factor NRF2. Through this mechanism, MOTS-c can turn on a suite of stress-defense and metabolic genes that help cells adapt to high-fat stress or insulin resistance

Gastrointestinal absorption of vitamin B 12depends on the presence of sufficient intrinsic factor and calcium ions

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In group B, BPC 157 (20 g/kg) was injected intraperitoneally 45 min after the laparotomy, with no further interventions
