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Description
Development of a water-soluble indolylmaleimide derivative IM-93 showing dual inhibition of ferroptosis and NETosis

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Hum Mol Genet (2010) 19(23):464353

6.5 Structural biology and payload-target interactions The successful integration of novel payloads into ID-ADCs fundamentally relies on structural biology, which enables rational design by elucidating specific interactions between the payload and its target

Conclusions In the last 5 years, existing knowledge about gastrointestinal dysfunction in PD with functional consequences on the oral drug-delivery strategy in PD have been extensively researched (Figure 5)
