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The critical role of CD4 + T cells was confirmed by showing that virus-based SYN-overexpression can only induce microglia activation and neurodegeneration when MHC-II is present (195)

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Human clinical trial data remains limited, with Phase I and II trials for inflammatory bowel disease conducted in the 1990s claiming safety with no toxicity, though full peer-reviewed data never appeared in scientific literature
Liu D, Qin H, Gao Y, Sun M, Wang M
