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Test tube studies shows that ALCAR donates a acetyl group to help make acetylcholine.[iii] Alzheimers-diseased brains show a 25% to 40% reduction in carnitine acetyltransferase , an enzyme that works with L-Carnitine & Acetyl-L-Carnitine

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An RCT comparing the effects of duloxetine and pregabalin showed an improvement in WPI scores with a statistically significant difference between the two treatment arms in favour of duloxetine [8]