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Inskip A, Elexperu-Camiruaga J, Buxton N, Dias PS, MacIntosh J, Campbell D et al

Furthermore, whilst loss of C9orf72 in mice models disturbs microglial function, resulting in age-related neuroinflammation, this was not sufficient to cause neurodegeneration in C9orf72 knockout mice (Lall and Baloh, 2017)

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These interactions highlight the multifaceted mechanisms by which polyphenols exert their therapeutic effects, targeting key pathological processes in AD, including oxidative stress, neuroinflammation, and synaptic dysfunction, thereby offering a promising avenue for therapeutic intervention