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Addiction 113, 19051926

chromatography e.g., ion exchange, affinity, particularly by affinity for the specific antigen after Protein A, and sizing column chromatography centrifugation e.g., centrifugation, differential solubility, or by any other standard technique for the purification of proteins

Moreover neurofibrillary tangles results from aggregation and hyperphosphorylation of tau protein [34]

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The development of optic nerve gliomas in these mice showed that astrocytoma formation requires NF1 heterozygosity and loss of NF1 in astrocytes and highlights this mouse model as one of the few preclinical models available for NF1-associated optic glioma (77)