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Official guidance from the Food and Drug Administration and Pfizer-BioNTech state that the two doses should be administered 21 days apart based on the results of clinical trials
In vivo study demonstrated that topical application of OPs on the skin significantly alleviated moisture loss, epidermal hyperplasia, as well as degradation of collagen and elastin fibers caused by chronic UVB irradiation
Nguyen et al., 2024
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Light pressure with a cotton ball is fine if there is bleeding
