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The 2025 Frontiers in Aging clinical review (Frontiers in Aging 2025) summarises the documented short-term adverse effects in adult populations: peripheral oedema and fluid retention are common at initiation, carpal tunnel syndrome occurs in a meaningful proportion of users, hyperglycaemia and insulin resistance can emerge because GH is physiologically counter-regulatory to insulin, and gynaecomastia has been reported, particularly at higher doses

[DOI] [PubMed] [Google Scholar] 114.Grinberg L., Fibach E., Amer J., Atlas D

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369 Additionally, CDKN2A, GLS, and MTF1 have been shown to correlate with cellular sensitivity to cuproptosis

Among these, ginsenoside Rg1 has gained particular attention due to its distinct neuroprotective effects