glutathione reductase in caco-2 cells differentiated Multilevel Proteomic Profiling of Colorectal Adenocarcinoma Cell Differentiation to Characterize an Intestinal Epithelial Model Involvement of glutathione peroxidases in

Roverato et al., 2021

They participate in the regulation of ferroptosis through the degradation of proteins and organelles, thereby controlling iron accumulation and lipid peroxidation

By screening appropriately and choosing compounds based on both mechanism and medical history, we can maximize regenerative benefits while minimizing oncologic risk

Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells

Key limitations include poorly characterized pharmacokinetics (rapid absorption but extensive metabolism and low systemic bioavailability for eugenol), variable extract standardization, heterogeneous assay methodologies, and limited in vivo and clinical data