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Note that uncertainty in the atomic weights themselves contributes an uncertainty of about 1 mg/kg to this definition

High doses are generally considered safe, though some people may experience minor side effects

With most drugs in psychiatry, though, short half-lives do not necessarily translate into earlier benefits, and where higher levels need to be attained sooner than can be attained by waiting for 5 half-lives, this is achieved by administering higher initial (loading) doses, or by crowding earlier doses and then spacing them out into the recommended dosing intervals

An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein