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In addition to this, there are some medical conditions like pernicious anemia or gastrointestinal disorders, where malabsorption is the main problem
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A large study of the genetic factors contributing to serum UA has identified 183 loci, but still only explains about 7.7% of the variance 5

J Healthc Eng

The term allergy was first coined in the early 1900s by Clemens von Pirquet (18741929), who was the first to recognize that antibodies not only mediate protective immune responses but can also be the cause of hypersensitivity reactions [9]

An elevated methylmalonic acid (MMA) level has been thought to be the most direct, metabolic indicator of B12 deficiency because B12 is the only cofactor required by the enzyme that degrades MMA
