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The main influencing factors are multidrug resistance to chemotherapy and resistance to radiotherapy [265]

[PubMed] [Google Scholar] 43.Huang C, Chang L, Anderson ME, Meister A

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When cancer occurs, the Hippo signaling becomes inactive, the unphosphorylated yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) enters the nucleus, and binds to the transcriptional enhanced associate domains (TEADs) transcription family, synergistically promoting the expression of target genes, enhancing cell proliferation, resistance to apoptosis, invasion and metastasis