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The aldo-keto reductases use NADH or NADPH to reduce MG to acetol, lactaldehyde or pyruvate 33,37,38,39

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Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway

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The evidence is preclinical , there are no human trials of PEG-MGF, and it is not FDA-approved

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Glutathione deficiency leads to mitochondrial damage in brain

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FIGURE 3 In the first step, the thiolate of glutathione acts as a base and deprotonates carbon C4

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