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Impaired mitochondrial metabolism is strongly associated with amyloid- toxicity, tau pathology, synaptic dysfunction, and neuronal loss (Reddy, 2011

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doi: 10.1038/srep45098 78 HiltonJ

To much production of oxidants results into oxidative damage to cells and matrix molecules in the gingival tissues, like lipid peroxidation, protein oxidation, and DNA damage, aggravating the severity and duration of the inflammatory response ( 2.3 Role of oxidative stress in the pathogenesis of periodontitis In the pathogenesis of periodontitis, oxidative stress is of great importance
