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2 A recent clinical epidemiological study showed that local anesthesia can potentially interferes with human permanent tooth development and induces tooth agenesis through unknown mechanisms
(2011PLoS ONE, 6 (3) DOI: 10.1371/journal.pone.0018046 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Inducers of Glucuronidation Induction of UGTs, and other Phase II enzymes is usually modest, several fold, in contrast to possible induction noted for P450s
doi: 10.1097/00005537-199906000-00001
doi: 10.1371/journal.pbio.2003705
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