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Next, we choose the lysis gene to achieve autolysis of bacteria

10.1016/j.lfs.2019.116836 34 RazaH.JohnA.HowarthF

An in vitro study using AD fibroblasts revealed a reduction of oxoglutarate dehydrogenase activity and it was further supported by an in vivo study with AD patients whereby the activity of oxoglutarate dehydrogenase complex was markedly reduced by 46 to 68% [201, 202]

Bioactive substances such as green tea catechins, silymarin, garlic ingredients, and certain flavonoids can directly limit their action by blocking NF-B nuclear translocation, inhibiting upstream kinases (IKK/ ), and preventing IB phosphorylation (5, 6, 36, 37)