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This research was supported by the Fondation Dormeur, Vaduz (to R.W.S

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It is often best to follow the guidance on the product label or your practitioners recommendation

Epithelial barrier function in vivo is sustained despite gaps in epithelial layers

Neuronal and in vivo studies tend to partially confirm this view, but also point to a greater level of complexity where post-endocytic sorting and multiplicity of regulatory mechanisms argue against a simple, universal strategy for reducing tolerance