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The dysregulation of the GSH/GPX4 axis, precipitating ferroptosis, significantly promotes IRI and the inhibitor lip-1 effectively counteracts hepatic damage [196]

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Zhang Y, Guo Q, Fang X, et al
26 Three out of the five RCTs reviewed in this meta-analysis showed improvements in at least one cognitive function outcome measure, and pooled data from three trials showed a significant improvement in working memory, whilst improvements in processing speed failed to reach statistical significance

Facial skin collagen significantly increased after 16 weeks of treatment
To prevent the irreversible cell damage, the increase of ROS induces an adaptive response, consisting in a compensatory upregulation of antioxidant systems, aimed to restore the redox homeostasis [3]
