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ALCAR for ME/CFS and Fibromyalgia Research on ALCAR in ME/CFS and fibromyalgia is promising: Energy Production: ALCAR improves mitochondrial function and enhances the activity of pyruvate dehydrogenase (PDH), a key enzyme impaired in ME/CFS

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Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66

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