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Pharmacol Biochem Behav 27 : 665670
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In recent years, intranasal (IN) drug delivery has emerged as a promising strategy to bypass the BBB, providing a direct nose-to-brain delivery route via olfactory and trigeminal pathways while minimizing systemic exposure
For example, the TM6SF2 E167K genotype associates with steatosis but not fibrosis, whereas MBOAT7 rs641738 is solely associated with increased fibrosis
Ferroptosis sensitivity is reestablished by inhibiting CSE with propargylglycine (PPG) [91]
