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Missing values were imputed, and significantly up- or down-regulated hits were determined by multiple-sample test (one-way ANOVA, s0 = 0.1, FDR = 0.05) and t test (two-sided, s0 = 0.1, FDR = 0.05)

Alcoholism can be considered an inflammatory condition, as peripheral endotoxemia may lead to brain inflammation and increased secretion of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin (IL)-1, IL-6, and interferon [35]

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