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Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length

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Birdsall TC (August 1998). 5-Hydroxytryptophan: a clinically-effectiveserotonin precursor. Alternative Medicine Review: a Journal of ClinicalTherapeutic 3 (4): 27180. PMID 9727088. Retrieved 2009-07-30.Turner EH, Loftis JM, Blackwell AD. Serotonin a la carte: supplementationwith the serotonin precursor 5-hydroxytryptophan. Pharmacol Ther. 2006Mar;109(3):325-38. Epub 2005 Jul 14.Izumi T, Iwamoto N, Kitaichi Y, Kato A, Inoue T, Koyama T. (2006).Effects of co-administration of a selective serotonin reuptake inhibitorand monoamine oxidase inhibitors on 5-HT-related behavior in rats. Eur JPharmacol. 532 (3): 258264. DOI:10.1016/j.ejphar.2005.12.075

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