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The overall quality of evidence for this outcome was low due to serious imprecision (low number of trials and participants)

Zhou N, Mitchell KG, Corsini EM, Truong VTT, Antonoff MB, Mehran RJ, Rajaram R, Rice DC , Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Ajani JA, Hofstetter WL

Thus, results of intervention trials of B vitamin supplementation are conflicting

Nevertheless, oxidative stress and H 2 O 2 were described to activate multiple stress-sensitive Ser/Thr kinases such as JNK, ERK1, and IKKb (inhibitor of NF- B), and p70S6k, which take part in insulin resistance by phosphorylation of IRS1 in serine instead of tyrosine residue, blocking insulin signaling [41]