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TUNEL staining showed that liver sections from mice in WT+PCPA and KO groups were more positively stained than mice in the WT and KO+5-HTP groups (Figure 3G)

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Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase

Indeed, genetic invalidation of JNK 5, 35 or activation of JNK prior to PH 36 decreases or improves hepatocyte proliferation, respectively