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The formulations or compositions disclosed herein alternatively encompass an otoprotectant agent in addition to the at least one active agent and/or excipients, including but not limited to such as antioxidants, alpha lipoic acid, calcium, fosfomycin or iron chelators, to counteract potential ototoxic effects that arise from the use of specific therapeutic agents or excipients, diluents, or carriers

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(Symptoms were skin thickening, like hard rubber, hair loss, skin biopsy with fibrosis, and abnormal calcification on mammograms and x-rays.) A 57-year-old woman exposed to MultiHance (plasma creatinine ranging from 0.9 to 1.2 mg/dL) developed edema and skin thickening of the lower extremities 3 months after exposure

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Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation