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Although an early study by Butler et al [58] demonstrated that non-hormone-expressing endocrine cells increase only modestly in islets in type 2 diabetes, by characterising the islet maturation programme at the transcriptional level during human ontogeny, Avrahami et al [59] demonstrated that a large fraction of beta cells in type 2 diabetes undergoes dedifferentiation, characterised by de-repression of immature genes

It also affects the hormone insulin and the function of chemical messengers in your brain

Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness