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In this respect, it is important to discriminate between tumors that express CA IX as a consequence of the inactivating mutation of pVHL tumor suppressor protein and tumors in which CA IX is present in connection with microenvironmental hypoxia and/or acidosis

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Research evidence for combination effects While direct head-to-head comparison studies of the combination versus individual peptides remain limited, the mechanistic evidence strongly supports synergistic interactions

Refer to Table 6: Treatment of folate deficiency for supplementation routes, dosage and duration

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