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Breast implant rupture is when the implant itself breaks or leaks

Since these early seminal studies, there has been much progress in identifying the fundamental control mechanisms underlying neurogenic propulsion in the small and large intestine of small vertebrates 5,6,1017 , including the small intestine 18 and colon 19 of humans, confirming that the ENS alone is capable of generating complex neurogenic motor patterns without inputs from the CNS (Fig.2)

Thomas Sydenham (1624-1689) described the lumps of uric acid (called tophi) that can be seen in gout, based on his own personal suffering

Disclosure of interest: Marina Guasch-Jimnez: received a research grant from the Cerebrovascular diseases group of the Spanish Neurology Society (Beca Proyecto Ictus 2022) Nicols Lpez-Hernndez: nothing to disclose Jess Juega: nothing to disclose Irene Alcobendas-Liern: nothing to disclose Emilio Rodrguez-Castro: nothing to disclose Sebastin Garca-Madrona: nothing to disclose Patricia de la Riva: nothing to disclose Manuel Medina-Rodrguez: nothing to disclose Patricia Calleja: nothing to disclose Roberto Muoz-Arrondo: nothing to disclose Blanca Serrano-Serrano: nothing to disclose Patricia Martnez-Snchez: nothing to disclose Herbert Tejada-Meza: nothing to disclose Laura Llull: nothing to disclose Pol Camps-Renom: nothing to disclose

That is, exogenous hormones may affect other medications by altering metabolism, while at the same time drug metabolism pathways may impact exogenous hormones used for therapy