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Whereas the food intake was increased by ~ 30% in O-SF1, carnitine plasma level and TMAO were increased by 54% compaed to L-ZSF1

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We examined whether Nrf1 and Nrf2 are important in the transcriptional regulation of the rat GCLC using Nrf1 and Nrf2 knockout (F1 and F2) and wild-type (WT) fibroblasts and found that Nrf1 and Nrf2 are important for the rat GCLC promoter activity despite absence of ARE