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USA 107 , 74677472 (2010)

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Intrinsic platinum resistance refers to tumors that fail to respond to initial platinum-based chemotherapy, leading to disease progression during first-line therapy or immediately after therapy

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In vitro, polar fractions of Mucuna pruriens seeds upregulate endothelial NO synthase (eNOS) and neuronal NO synthase (nNOS), which in turn stimulate the production of NO and maintain intracellular levels of cGMP

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