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They play a crucial role in the regulation of synaptic networks by modulating neurotransmitter release at the presynaptic sites and by participating in membrane depolarization at postsynapses 4

Major challenges include figuring out the complex molecular interaction mechanisms between them and finding unique biomarkers, particularly in vivo

The circadian rhythm in cartilage is considered an important regulatory mechanism for tissue homeostasis and OA development [139]

While iron is incredibly important to the proper operation of many different biological systems, it can also cause free radical damage if it isn't properly handled

levels decline with age, contributing to slower recovery and visible aging