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More than 25 allelic variants of NAT1 and NAT2 have been characterized, and in individuals in whom acetylation of drugs is compromised, homozygous genotypes for at least 2 variant alleles are required to predispose a patient to lowered drug metabolism

An increased kynurenine/tryptophan (Kyn/Trp) ratio correlates with disease The kynurenine pathway is a major route of tryptophan metabolism in humans, in which the enzyme indoleamine 2,3-dioxygenase ( IDO1 ) converts tryptophan to kynurenine via the intermediate N-formyl L-kynurenine, followed by deformylation mediated by arylformamidase [58,59,60], for a schematic illustration, see Fig

X-rays alone take flat, 2D images